BUTILIFE® Fish Collagen Tripeptide
What Is Collagen Tripeptide and Why Is It Superior?
Collagen tripeptide (CTP) is a highly bioavailable form of collagen composed of three amino acids arranged in a repeating Gly-X-Y sequence—typically glycine, proline or hydroxyproline, and another amino acid.
This unique triple-helix structure is made up of around 20 different amino acids and mirrors the natural structure of human collagen.
Unlike regular collagen peptides, collagen tripeptides have a significantly lower molecular weight, allowing them to be absorbed directly in the small intestine without further breakdown. Scientific studies show that when equal amounts of collagen peptides and collagen tripeptides are consumed, the concentration of collagen tripeptides in human plasma is considerably higher over time.
This indicates that CTP has up to five times greater bioavailability than ordinary collagen peptides, making it an ideal choice for rapid and effective collagen replenishment.
Why Formulators Choose BUTILIFE® Fish Collagen Tripeptide?
>95% Absorption Rate
Directly absorbed by small intestine
High Hydroxyproline (12.26%)
Exceeds national standard
Nano-Molecular Size (~500 Da)
Maximum bioavailability
Patented Multi-Enzyme Hydrolysis
Specific to tripeptide release
Clear Taste, Fully Soluble
No bitterness, fishy smell, or residue
Patented Collagen Peptide Technologies: Precision-Engineered for Maximum Bioactivity
🧪 Nano-Peptide Purification (Patent No. ZL202221480883.7)
Our proprietary nano-level peptide purification technology enhances solubility and thermal stability of ultra-small collagen peptides—ideal for functional foods, nutraceuticals, and skincare formulations.
⚙ High-Yield Tripeptide Technology (Patent No. ZL202320392239.2)
Through optimized reaction conditions and advanced bioreactor control, this patented process significantly increases the yield of Gly-Pro-Hyp-rich peptides for maximum efficacy in absorption and performance.
🌿 Bio-Enzymatic Hydrolysis with Mild Processing (Patent No. ZL201820444344.5)
This patented enzymatic hydrolysis method uses low-temperature, gentle processing to retain the integrity and bioactivity of functional peptides. The resulting collagen peptides are further refined into smaller molecular weights, improving absorption and bioavailability in the human body.
🔬 Enzyme-Specific Hydrolysis
Utilizing multi-enzyme systems for targeted enzymatic hydrolysis, this process precisely isolates collagen tripeptides, especially Gly-Pro-Hyp, ensuring high bioactivity and functional consistency.
Premium-Grade Collagen Peptide Powder with Superior Solubility and Stability
Our collagen tripeptide powder is a white, fine-textured ingredient with an average molecular weight of approximately 500 Daltons, ensuring optimal absorption and bioavailability.
It contains 12.26% hydroxyproline, a key indicator of collagen quality. The product dissolves fully into a clear, bright solution without any bitterness or fishy odor, making it ideal for applications in beverages, supplements, and functional foods.
Its exceptional stability under varying pH levels, heat, and salinity further enhances its versatility across formulations. Packaged securely in 1kg foil bags or 15kg PE-lined cartons, the product maintains a shelf life of 24 months under cool, dry storage conditions.
| Property | Description |
|---|---|
| Appearance | White fine powder |
| Molecular Weight | ~500 Daltons |
| Hydroxyproline | 12.26% |
| Solubility | Fully soluble, clear & bright solution |
| Taste | Neutral, no bitterness or fishy flavor |
| Stability | Excellent under pH, heat, and salt |
| Packaging | 1kg/foil bag; 15kg/PE+carton |
| Shelf Life | 24 months (unopened, cool & dry place) |
Clinically Evaluated Collagen Peptides for Skin Elasticity, Firmness, Whitening & Antioxidant Protection
Backed by in vitro and in vivo studies, BUTILIFE® fish collagen tripeptides demonstrate a wide range of clinically supported skincare benefits. Zebrafish tail fin testing reveals a 17% improvement in skin elasticity with increasing peptide concentrations, highlighting its anti-wrinkle and firming effects. Human fibroblast (HFF-1) assays show significant upregulation of Collagen-Iα1 expression at 6 mg/mL, confirming its firming efficacy.
In B16 melanocyte studies, fish tripeptides effectively suppress tyrosinase activity and melanin production—achieving optimal whitening effect at 400 μg/mL. Furthermore, BUTILIFE® exhibits powerful antioxidant properties, including strong DPPH radical scavenging and elevated SOD activity, offering protection against oxidative stress and UV-induced skin damage. These results support its application in premium anti-aging, whitening, and nutricosmetic formulations.
As the concentration of BUTILIFE® fish collagen tripeptides increases, the oral anti-wrinkle efficacy improves correspondingly. At a concentration of 1000 μg/mL, the anti-wrinkle effect surpasses that of the positive control group, achieving a 17% improvement.
These results demonstrate that BUTILIFE® effectively reduces wrinkles and enhances skin elasticity through oral supplementation.
In a 72-hour in vitro study using HFF-1 human fibroblast cells, BUTILIFE® fish collagen tripeptides demonstrated a significant firming effect. When applied at a concentration of 6 mg/mL, the level of Collagen-Iα1—a key marker of skin firmness and structural integrity—was significantly elevated compared to the negative control (NC) group.
The study involved repeated exposure over three days, with fresh media and peptide concentrations replenished at 24 and 48 hours. Results were quantified using ELISA assays, confirming BUTILIFE®’s efficacy in promoting collagen synthesis and enhancing skin-tightening potential at the cellular level.
Effect of BUTILIFE® Fish Collagen Tripeptides on Collagen-Iα1 Expression (HFF-1 Cells)
| Group | Collagen-Iα1 Concentration (pg/mL) | P Value |
|---|---|---|
| Negative Control (NC) | Not detected | — |
| Positive Control (PC) | 53.99 ± 4.14 *** | <0.001 |
| Test Sample (TA) 6 mg/mL | 40.42 ± 1.44 * | 0.017 |
| Test Sample (TA) 3 mg/mL | 2.73 ± 4.82 | 0.145 |
| Test Sample (TA) 1.5 mg/mL | Not detected | — |
*Statistical significance compared to NC group: * P < 0.05; *** P < 0.001
BUTILIFE® Fish Collagen Tripeptides have demonstrated impressive skin-brightening potential by effectively inhibiting tyrosinase activity and melanin production in B16 melanoma cells.
At a concentration of 400 μg/mL, tyrosinase activity reached its lowest level compared to the control group, indicating strong melanin-suppressing power.
Even at lower concentrations ranging from 50 to 400 μg/mL, the tripeptides significantly reduced melanin content within the cells, with the most notable reduction observed at 50 μg/mL.
These results highlight the whitening potential of BUTILIFE® CTP — a natural and science-backed solution to support radiant, even-toned skin.
BUTILIFE® Fish Collagen Tripeptides (CTP) demonstrate exceptional antioxidant power, effectively neutralizing free radicals and protecting cells from oxidative stress. With the lowest IC50 value among test groups, CTP shows the strongest DPPH radical scavenging activity, indicating its superior ability to combat free radicals.
Compared to both the untreated control and other peptide formulations (e.g., CP2), the CTP group exhibited a significantly lower average malondialdehyde (MDA) level, a key marker of lipid peroxidation. Additionally, CTP notably enhanced superoxide dismutase (SOD) activity, outperforming CP2 in restoring the body’s natural antioxidant defenses.
These findings confirm that CTP not only shields the skin from oxidative damage, including UV-induced aging, but also supports healthier, more resilient skin from within.
BUTILIFE® vs. Standard Collagen Peptides: A Clinical-Grade Comparison
BUTILIFE® Fish Collagen Tripeptides (CTP) stand far ahead of standard collagen peptides in absorption, molecular weight, bioavailability, and sensory qualities. With an ultra-low molecular weight (~500 Da) and a hydroxyproline content of 12.26%, BUTILIFE® ensures faster and more effective cellular uptake. Unlike conventional collagen with fishy taste and poor solubility, BUTILIFE® CTP is clear, odorless, instantly soluble, and clinically optimized for superior skin, joint, and antioxidant benefits.
Whether you’re formulating nutricosmetics, functional beverages, or skincare supplements, BUTILIFE® delivers premium results backed by science.
| Feature | BUTILIFE® CTP | Standard Collagen Peptides |
|---|---|---|
| Absorption Efficiency | >95% | ~20–30% |
| Hydroxyproline Content | 12.26% | <8% |
| Molecular Weight | ~500 Da | 1000–3000 Da |
| Taste / Clarity | No odor, clear | Bitter, fishy, turbid |
| Solubility | Instant, complete | Slow, may leave residue |
BUTILIFE® Fish Collagen Tripeptides for Functional Foods, Drinks & Beauty Formulations
BUTILIFE® Fish Collagen Tripeptides are engineered for maximum bioavailability, taste neutrality, and solubility—making them an ideal ingredient for diverse applications across the nutricosmetic, functional food, and personal care industries. Whether incorporated into oral beauty supplements, functional beverages, or cosmeceutical skincare, BUTILIFE® delivers scientifically backed performance and formulation flexibility to help your brand meet evolving consumer demands for beauty-from-within and holistic wellness.
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